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ASOHNS ASM 2025
ASOHNS ASM 2025
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Solitary neurofibroma of the larynx: a rare case report and review of the literature

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Institution: Eastern Health - Victoria, Australia

Aims: Neurofibromas as benign peripheral nerve sheath tumours. While generally these are not associated with neurofibromatosis type-1 (NF1), reports of solitary laryngeal neurofibromas are rare. This study aims to investigate the presentation, investigation and management of these cases. A rare case of 56-year-old male with a solitary neurofibroma in the right false cord is also described. He presented with a 6-month history of dysphonia, and following finding of a cystic lesion in his larynx on CT scan, he underwent CO2 laser resection and was free of recurrence in the 8-month surveillance period. Methodology: A search of Pubmed and MEDLINE for solitary neurofibromas of the larynx was performed. Non-English articles, incomplete case reports, neurofibromas related to neurofibromatosis type-1 and non-laryngeal neurofibromas were excluded. Results: 142 articles were screened of which 22 were included in this study. Of the 25 cases reported, the average age of patients presenting was 43 years old. There was a slight female predilection with 56% of reports being female and 44% being male. Most were found in the aryepiglottic fold (32%). Presenting symptoms varied but most reported dysphonia and dysphagia, while only 2 were incidentally found. Excision was performed either via laser or cold steel excision via a microlaryngoscopic approach but there were 3 reports of external approaches in the literature. Recurrence was only reported in 2 cases but there was a lack of data in the literature regarding this. Conclusion: Neurofibromas are rarely found in the larynx, and usually associated with neurofibromatosis at this subsite. 22 reports of solitary laryngeal neurofibromas have been identified in the literature. Most of these patients were adults at presentation and presented with a history of dysphonia or dysphagia. Excision has been reported by different approaches, and generally had good outcomes with low recurrence rates.

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Dr Fady Daniel - , Mr Sor Way Chan -