Aims The development of computer/ physical models to represent the upper airway has progressed from a “head cut in half” to models with functional movements and ultrashort echo-time (UTE) MRI data [1]. The developments of technologies as well as the requirements of modelling programs have driven this improvement in airway models. Methodology A review of the literature shows how the role of airway models has improved, and the implications this has on drug delivery and treatments of respiratory ailments. The risks and benefits of these developments in airway models are highlighted. Results The results show advancements in CFD programming focused specifically on human airway applications. However, the findings also show some oral inhalation models have used closed mouth, nose breathing CT scans to investigate oral particle inhalation. The physical implication is that the soft palate is lowered, the jaw has not dropped to introduce a device piece into the mouth [2]. Conclusion Human airway models have come a long way since 1951, the journey will continue to shape how we are able to improve our treatments of respiratory ailments, but it is our responsibility to ensure appropriate models are used. References: 1.Gunatilaka CC, McKenzie C, Xiao Q, Higano NS, Woods JC, Bates AJ. Effect of airway wall motion on particle deposition and delivery in the neonatal trachea. Journal of Aerosol Science. 2024;182:106450. 2.1. Frank‐Ito DO, Cohen SM. Orally Inhaled Drug Particle Transport in Computerized Models of Laryngotracheal Stenosis. Otolaryngol--head neck surg. 2021;164(4):829-840